Triethylamine → ethyl 2-amino-2-phenylbutanoate

HRID 1445957Notes

Reaction equation

HRID 1445957 reaction equation
Cl.[NH2:2][C:3]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([CH2:9][CH3:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5].C(N(CC)CC)C>C1COCC1>[NH2:2][C:3]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)([CH2:9][CH3:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 67234749HCID 67234749, compound

Product 1

HCID 10488547ethyl 2-amino-2-phenylbutanoateYield 77%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The crude product 5 was dissolved in 22 mL of anhydrous THF and 2.64 mL of triethyl amine were added. After stirring for 30 minutes, the mixture was filtered through celite and the solid washed with 100 mL of anhydrous diethyl ether. Concentration of the solvents using a rotary evaporator afforded 2.49 g of 6 as a blue oil (77% yield).

Workup

  1. filtrationthe mixture was filtered through celite
  2. washthe solid washed with 100 mL of anhydrous diethyl ether
  3. customa rotary evaporator

Sources & evidence

ORD record
ord-3268f9f635b74e049a18cc64221acc74
Source dataset
uspto-grants-2010_02
Patent number
US07666907B2

Reaction notes

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