Diethylamine → HCID 24808145, compound

HRID 1446018Notes

Reaction equation

HRID 1446018 reaction equation
CC([O:4][C@H:5]1[C:14]2[C@@:15]3([CH3:30])[C@@H:26]([CH2:27][O:28][CH3:29])[O:25][C:23](=[O:24])[C:17]4=[CH:18][O:19][C:20]([C:21](=[O:22])[C:13]=2[C@@H:8]2[CH2:9][CH2:10][C@H:11]([OH:12])[C@@:7]2([CH3:31])[CH2:6]1)=[C:16]34)=O.[CH2:32]([NH:34][CH2:35][CH3:36])[CH3:33]>CO>[CH2:32]([N:34](/[CH:18]=[C:17]1/[C:23](=[O:24])[O:25][C@H:26]([CH2:27][O:28][CH3:29])[C@@:15]2([CH3:30])[C:16]/1=[C:20]([OH:19])[C:21](=[O:22])[C:13]1[C@H:8]3[C@:7]([CH3:31])([CH2:6][C@@H:5]([OH:4])[C:14]2=1)[C@@H:11]([OH:12])[CH2:10][CH2:9]3)[CH2:35][CH3:36])[CH3:33]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 986734017beta-Hydroxy wortmannin

Product 1

HCID 24808145HCID 24808145, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 17-hydroxywortmannin (1100 mg) in methanol (5 mL) is added diethylamine (0.72 mL). After 48 hours the reaction mixture is concentrated under vacuum. The residue is dissolved in EtOAc and precipitated with hexane. A yellow powder is obtained (0.29 mg). MS: 462.2 (M+H)+.

Workup

  1. concentrationAfter 48 hours the reaction mixture is concentrated under vacuum
  2. dissolutionThe residue is dissolved in EtOAc
  3. customprecipitated with hexane
  4. customA yellow powder is obtained (0.29 mg)

Sources & evidence

ORD record
ord-6977c54279744414a3cbfd4799c10a7e
Source dataset
uspto-grants-2010_02
Patent number
US07666901B2

Reaction notes

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