Diethylamine → 5-(4-Bromophenyl)-N,N-diethylisoxazole-4-carboxamide

HRID 1446162Notes

Reaction equation

HRID 1446162 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[CH2:16]([NH:18][CH2:19][CH3:20])[CH3:17]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([N:18]([CH2:19][CH3:20])[CH2:16][CH3:17])=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 228317015-(4-Bromophenyl)-1,2-oxazole-4-carboxylic acid

Product 1

HCID 248098885-(4-Bromophenyl)-N,N-diethylisoxazole-4-carboxamide

Procedure

The title compound was prepared from 5-(4-bromophenyl)isoxazole-4-carboxylic acid (13.4 mg, 0.050 mmol) and diethylamine (4.4 mg, 0.060 mmol) as described in synthetic method A and thereafter purified by preparative HPLC method A to give a solid (3.8 mg). MS (pos) m/z 323.0 and 325.0.

Workup

  1. custompurified by preparative HPLC method A

Sources & evidence

ORD record
ord-72c35c1673894d37ac73f9f39779cf94
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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