Diethylamine → N,N-Diethyl-5-(4-fluorophenyl)isoxazole-4-carboxamide

HRID 1446166Notes

Reaction equation

HRID 1446166 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[CH:10][C:9]=2[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[CH2:16]([NH:18][CH2:19][CH3:20])[CH3:17]>>[CH2:16]([N:18]([CH2:19][CH3:20])[C:13]([C:9]1[CH:10]=[N:11][O:12][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)=[O:15])[CH3:17]

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 37233755-(4-Fluorophenyl)isoxazole-4-carboxylic acid

Product 1

HCID 24809892N,N-Diethyl-5-(4-fluorophenyl)isoxazole-4-carboxamide

Procedure

The title compound was prepared from 5-(4-fluorophenyl)isoxazole-4-carboxylic acid (10.4 mg, 0.050 mmol) and diethylamine (4.4 mg, 0.060 mmol) as described in synthetic method A and thereafter purified by preparative HPLC method A to give a solid (11.4 mg). MS (pos) m/z 263.1 (M+1).

Workup

  1. custompurified by preparative HPLC method A

Sources & evidence

ORD record
ord-a9c474a32c484e5b9c8603f8e9f62aea
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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