Diethylamine → HCID 24809894, compound

HRID 1446167Notes

Reaction equation

HRID 1446167 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][N:13]=[CH:12][C:11]=2[C:15]([OH:17])=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH2:18]([NH:20][CH2:21][CH3:22])[CH3:19]>>[CH2:18]([N:20]([CH2:21][CH3:22])[C:15]([C:11]1[CH:12]=[N:13][O:14][C:10]=1[C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=1)=[O:17])[CH3:19]

Participants

3

Reactant 2

HCID 8021DiethylamineHCID 228317075-(4-Nitrophenyl)-1,2-oxazole-4-carboxylic acid

Product 1

HCID 24809894HCID 24809894, compound

Procedure

The title compound was prepared from 5-(4-nitrophenyl)isoxazole-4-carboxylic acid (11.7 mg, 0.050 mmol) and diethylamine (4.4 mg, 0.060 mmol) as described in synthetic method A and thereafter purified, first by preparative HPLC method A and then by method B, to give a solid (4.3 mg). MS (pos) m/z 290.2 (M+1).

Workup

  1. custompurified, first by preparative HPLC method A

Sources & evidence

ORD record
ord-cf6a9eedb47841c09209df0299ba7cc7
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

Loading…