Pyrrolidine → HCID 24809923, compound

HRID 1446171Notes

Reaction equation

HRID 1446171 reaction equation
[C:1]1([C:7]2[O:11][N:10]=[CH:9][C:8]=2[C:12]([OH:14])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[C:1]1([C:7]2[O:11][N:10]=[CH:9][C:8]=2[C:12]([N:15]2[CH2:19][CH2:18][CH2:17][CH2:16]2)=[O:14])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 147872535-Phenylisoxazole-4-carboxylic acid

Product 1

HCID 24809923HCID 24809923, compound

Procedure

The title compound was prepared from 5-(phenyl)isoxazole-4-carboxylic acid (9.5 mg, 0.050 mmol) and pyrrolidine (4.3 mg, 0.060 mmol) as described in synthetic method A and thereafter purified, first by preparative HPLC method A and then by method B, to give a solid (12.9 mg). MS (pos) m/z 243.2 (M+H).

Workup

  1. custompurified, first by preparative HPLC method A

Sources & evidence

ORD record
ord-4c7c64cd7b4b4cebb0c95c41be6364ce
Source dataset
uspto-grants-2010_02
Patent number
US07666888B2

Reaction notes

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