Hydrochloric Acid → ((3S)-1-(3,4-difluorobenzyl)pyrrolidine-3-yl)amine dihydrochloride

HRID 1446515Notes

Reaction equation

HRID 1446515 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[C:16]([F:21])[CH:15]=2)[CH2:9]1)(C)(C)C.[ClH:23]>C(OCC)(=O)C>[ClH:23].[ClH:23].[F:21][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][C:17]=1[F:20])[CH2:13][N:10]1[CH2:11][CH2:12][C@H:8]([NH2:7])[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66961515(3S)-(1-(3,4-difluorobenzyl)pyrrolidin-3-yl)carbamic acid tert-butyl ester

Product 1

HCID 66960173((3S)-1-(3,4-difluorobenzyl)pyrrolidine-3-yl)amine dihydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To an ethyl acetate solution (5 mL) of (3S)-(1-(3,4-difluorobenzyl)pyrrolidin-3-yl)carbamic acid tert-butyl ester (1.55 g), an ethyl acetate (5 mL) solution of 4N hydrochloric acid was added, and the reaction solution was agitated at room temperature. Deposited substances in the reaction solution was separated by filtering after 10 hours, and 904 mg of the title compound was obtained by further washing with ether. The physical properties of the compound are as follows.

Workup

  1. customDeposited substances in the reaction solution was separated
  2. filtrationby filtering after 10 hours

Sources & evidence

ORD record
ord-c319904fcbda436ab0c379ca689253c6
Source dataset
uspto-grants-2010_02
Patent number
US07667041B2

Reaction notes

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