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HRID1446653

反应详情

EQUATION

反应方程式

HRID 1446653 的结构方程式

REACTANTS

反应物

4
结构：c1c[nH]cn1
HCID795

Imidazole

C3H4N2

结构：CCOC(C)=O
HCID8857

Ethyl acetate

C4H8O2

结构：CC(C)(C)[Si](C)(C)Cl
HCID28928

Chloro(1,1-dimethylethyl)dimethylsilane

C6H15ClSi

结构：CC(C)(C)c1cc(N)n(CCO)n1
HCID16227877

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)c1cc(N)n(CCO[Si](C)(C)C(C)(C)C)n1
HCID68546544

3-(1,1-Dimethylethyl)-1-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-1H-pyrazol-5-amine

C15H31N3OSi

收率 99%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O
溶剂HCID962

Water

H2O

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

To 2-(5-amino-3-tert-butyl-pyrazol-1-yl)-ethanol (3.42 g, 0.019 mol), add TBDMSCl (3.38 g, 1.2 equiv.) and imidazole (3.18 g, 2.5 equiv.) in DMF (7 mL) and stir overnight at room temperature under N2. Dilute the reaction with ethyl acetate and water. Wash the organic layer with water then saturated aqueous saturated sodium chloride and then dry over magnesium sulfate, filter, and concentrate in vacuo to give a solid (5.5 g, 99%) which is used without further purification. MS (ES), m/z 298 (M+1).

WORKUP

后处理

  1. additionDilute
  2. washWash the organic layer with water
  3. dry with materialsaturated aqueous saturated sodium chloride and then dry over magnesium sulfate
  4. filtrationfilter
  5. concentrationconcentrate in vacuo