Hydrochloric Acid → HCID 68542065, compound

HRID 1446709Notes

Reaction equation

HRID 1446709 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:19]3[CH:20]=[CH:21][C:22]([C:24]4[CH:29]=[CH:28][N:27]=[C:26]([CH2:30][N:31]([CH2:34][CH3:35])[CH2:32][CH3:33])[CH:25]=4)=[CH:23][C:18]3=[N:17][CH:16]=2)=[CH:11][CH:10]=1)(C)(C)C.[ClH:37]>O1CCOCC1>[ClH:37].[ClH:37].[ClH:37].[NH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:19]3[CH:20]=[CH:21][C:22]([C:24]4[CH:29]=[CH:28][N:27]=[C:26]([CH2:30][N:31]([CH2:34][CH3:35])[CH2:32][CH3:33])[CH:25]=4)=[CH:23][C:18]3=[N:17][CH:16]=2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68541287HCID 68541287, compound

Product 1

HCID 68542065HCID 68542065, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

Dissolve {4-[7-(2-diethylaminomethyl-pyridin-4-yl)-imidazo[1,2-a]pyridin-3-yl]-benzyl}-carbamic acid tert-butyl ester (0.24 g, 0.49 mmol) in dioxane (10 mL) under nitrogen. Add 4 M HCl in dioxane (5 mL) to the reaction and stir for 2 hours. Concentrate to dryness and use crude as the tri-HCl salt (0.321 g, crude). MS (ES), m/z 386.2 (M+1).

Workup

  1. customto the reaction
  2. concentrationConcentrate to dryness and use crude as the tri-HCl salt (0.321 g, crude)

Sources & evidence

ORD record
ord-779c35361b6e475c88caf76ccc0d518b
Source dataset
uspto-grants-2010_02
Patent number
US07666879B2

Reaction notes

Loading…