Hydrochloric Acid → HCID 86634308, compound

HRID 1446739Notes

Reaction equation

HRID 1446739 reaction equation
[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[N:24]4[CH:25]=[CH:26][C:27]([C:29]5[CH:34]=[CH:33][N:32]=[C:31]([CH2:35][CH2:36][CH:37](OCC)[O:38]CC)[CH:30]=5)=[CH:28][C:23]4=[N:22][CH:21]=3)=[CH:16][C:15]=2[F:44])=[O:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[ClH:45]>C(OCC)(=O)C>[ClH:45].[C:1]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[N:24]4[CH:25]=[CH:26][C:27]([C:29]5[CH:34]=[CH:33][N:32]=[C:31]([CH2:35][CH2:36][CH:37]=[O:38])[CH:30]=5)=[CH:28][C:23]4=[N:22][CH:21]=3)=[CH:16][C:15]=2[F:44])=[O:12])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68543404HCID 68543404, compound

Product 1

HCID 86634308HCID 86634308, compoundYield 105%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Slurry 1-(5-tert-butyl-isoxazol-3-yl)-3-(4-{7-[2-(3,3-diethoxy-propyl)-pyridin-4-yl]-imidazo[1,2-a]pyridin-3-yl}-2-fluoro-phenyl)-urea (1 g, 1.7 mmol) in ethyl acetate (35 mL). Add aqueous 1 N HCl (3.3 mL, 2 equiv.) and stir at room temperature. After 1.5 hours, concentrate to dryness to give an orange solid (0.98 g, 105%). MS (ES), m/z 527 (M+1).

Workup

  1. concentrationconcentrate to dryness

Sources & evidence

ORD record
ord-c7d592abe1544fea90d3be396883f71a
Source dataset
uspto-grants-2010_02
Patent number
US07666879B2

Reaction notes

Loading…