Hydrochloric Acid → HCID 68542631, compound

HRID 1446772Notes

Reaction equation

HRID 1446772 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:50])[C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][N:24]4[C:27]([C:30]5[CH:35]=[CH:34][C:33]([NH:36][C:37]([NH:39][C:40]6[CH:44]=[C:43]([C:45]([CH3:48])([CH3:47])[CH3:46])[O:42][N:41]=6)=[O:38])=[C:32]([F:49])[CH:31]=5)=[CH:28][N:29]=[C:23]4[CH:22]=3)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:51]>C(Cl)Cl>[ClH:51].[C:45]([C:43]1[O:42][N:41]=[C:40]([NH:39][C:37]([NH:36][C:33]2[CH:34]=[CH:35][C:30]([C:27]3[N:24]4[CH:25]=[CH:26][C:21]([C:18]5[CH:19]=[CH:20][C:15]([C:14]([N:11]6[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]6)=[O:50])=[CH:16][CH:17]=5)=[CH:22][C:23]4=[N:29][CH:28]=3)=[CH:31][C:32]=2[F:49])=[O:38])[CH:44]=1)([CH3:48])([CH3:46])[CH3:47]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68541670HCID 68541670, compound

Product 1

HCID 68542631HCID 68542631, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dissolve 4-[4-(3-{4-[3-(5-tert-Butyl-isoxazol-3-yl)-ureido]-3-fluoro-phenyl}-imidazo[1,2-a]pyridin-7-yl)-benzoyl]-piperazine-1-carboxylic acid tert-butyl ester (1.53 g, 2.24 mmol) in CH2Cl2 (25 mL), to which is added HCl (5.6 mL, 4 M in dioxane). Stir at room temperature for three hours, then concentrate in vacuo to give light brown solid as product (1.60 g, 115%). MS (ES), m/z 582 (M+1, free base).

Workup

  1. concentrationconcentrate in vacuo
  2. customto give light brown solid as product (1.60 g, 115%)

Sources & evidence

ORD record
ord-84f88cc1c1cf4e34a0d549c0f0dda285
Source dataset
uspto-grants-2010_02
Patent number
US07666879B2

Reaction notes

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