2,5-Difluoronitrobenzene → 2,5-Difluoroaniline

HRID 1446775Notes

Reaction equation

HRID 1446775 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[N+:9]([O-])=O.[H][H]>O1CCCC1.[Ni]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[NH2:9]

Participants

5

Reactant 2

HCID 677672,5-DifluoronitrobenzeneHCID 178418361HCID 178418361, compound

Product 1

HCID 677752,5-Difluoroaniline

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2,5-difluoronitrobenzene in tetrahydrofuran containing Raney nickel catalyst, in a Parr shaker, was treated with hydrogen at room temperature to give 2,5-difluoroaniline (2A).

Sources & evidence

ORD record
ord-94d33c196f004f1098815ff93a4b2e3c
Source dataset
uspto-grants-1982_02
Patent number
US04313755

Reaction notes

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