1-Methylpiperazine → 3,6-Bis[2-(4-methylpiperazin-1-yl)ethoxy]acridine

HRID 1446918Notes

Reaction equation

HRID 1446918 reaction equation
Cl.Cl[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]2[C:18]([CH:19]=1)=[N:17][C:16]1[C:11](=[CH:12][CH:13]=[C:14]([O:20][CH2:21][CH2:22]Cl)[CH:15]=1)[CH:10]=2.[CH3:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[CH3:24][N:25]1[CH2:30][CH2:29][N:28]([CH2:3][CH2:4][O:5][C:6]2[CH:7]=[CH:8][C:9]3[C:18]([CH:19]=2)=[N:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:20][CH2:21][CH2:22][N:28]4[CH2:29][CH2:30][N:25]([CH3:24])[CH2:26][CH2:27]4)[CH:15]=2)[CH:10]=3)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 201846653,6-Bis(2-chloroethoxy)acridine--hydrogen chloride (1/1)

Product 1

HCID 205534563,6-Bis[2-(4-methylpiperazin-1-yl)ethoxy]acridine

Conditions

Temperature
100 °C

Procedure

The compound is prepared from 3,6-bis(2-chloroethoxy)acridine hydrochloride and N-methylpiperazine as described in Example 15, except that the mixture is heated at 100° C. for 24 hours to attain reaction and that the free base is isolated.

Workup

  1. customreaction
  2. customthat the free base is isolated

Sources & evidence

ORD record
ord-64be7bc7a21346ffae60dcf0ca51187b
Source dataset
uspto-grants-1982_02
Patent number
US04314061

Reaction notes

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