Hydrochloric Acid → HCID 12811218, compound

HRID 1446961Notes

Reaction equation

HRID 1446961 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[NH:4][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:6][N:7]=1.[Br:14]Br.Cl>C(=O)([O-])[O-].[K+].[K+]>[F:13][C:2]([F:1])([F:12])[C:3]1[NH:4][C:5]([C:8]([F:9])([F:10])[F:11])=[C:6]([Br:14])[N:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24408BromineHCID 12811210HCID 12811210, compound

Product 1

HCID 12811218HCID 12811218, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 11430Potassium CarbonateSolvent

Procedure

2,5-bistrifluoromethylimidazole is dissolved in an aqueous solution of potassium carbonate. Bromine 1.1 equivalents is added and heated until color dissipates. Solution is acidified with dilute hydrochloric acid and extracted with ether. The ether layer is washed once with brine solution, dried over sodium sulfate and stripped to give product in 64% yield.

Workup

  1. temperatureheated until color dissipates
  2. extractionextracted with ether
  3. washThe ether layer is washed once with brine solution
  4. dry with materialdried over sodium sulfate
  5. customto give product in 64% yield

Sources & evidence

ORD record
ord-6bd1f4f8099a48b1bbb1c6f7c2623b0a
Source dataset
uspto-grants-1982_02
Patent number
US04314844

Reaction notes

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