Trifluoroacetic anhydride → HCID 178512621, compound

HRID 1446988Notes

Reaction equation

HRID 1446988 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH2:16])[CH:11]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3].[F:17][C:18]([F:29])([F:28])[C:19]([O:21][C:22](=[O:27])[C:23]([F:26])([F:25])[F:24])=[O:20]>C(#N)C>[F:17][C:18]([F:29])([F:28])[C:19]([OH:21])=[O:20].[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([NH:16][C:22](=[O:27])[C:23]([F:24])([F:25])[F:26])[CH:11]=2)[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

4

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 1785126111-(4-(3-Aminophenyl)thiazol-2-yl)guanidine

Product 1

HCID 178512621HCID 178512621, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 2-guanidino-4-(3-aminophenyl)-thiazole (1.2 g.) and trifluoroacetic anhydride (1.05 g.) was heated under reflux in acetonitrile for 3 hours. The mixture was cooled and the product (0.76 g.) filtered off to give 2-guanidino-4-(3-trifluoroacetylaminophenyl)thiazole trifluoroacetate, m.p. 152°-153° C.

Workup

  1. temperaturewas heated
  2. temperatureThe mixture was cooled
  3. filtrationthe product (0.76 g.) filtered off

Sources & evidence

ORD record
ord-0777e3cd6a964f2bb96956c150017e99
Source dataset
uspto-grants-1982_02
Patent number
US04315009

Reaction notes

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