Chloroform → HCID 20552302, compound

HRID 1447011Notes

Reaction equation

HRID 1447011 reaction equation
S(Cl)([Cl:3])=O.[C:5]1([CH:11](O)[CH2:12][N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.C(Cl)(Cl)[Cl:20]>CN(C)C=O>[ClH:3].[C:5]1([CH:11]([Cl:20])[CH2:12][N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 6212ChloroformHCID 24386Thionyl ChlorideHCID 10081198HCID 10081198, compound

Product 1

HCID 20552302HCID 20552302, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

31 parts by weight of thionyl chloride is dripped into 25 parts by weight of 1-[2-phenyl-2-hydroxyethyl]-1,2,4-triazole, 300 parts by weight of chloroform and 1 part by weight of dimethylformamide; the mixture is refluxed until no more gas evolves. After the mixture has been cooled and filtered, the residue is washed with a small amount of chloroform and recrystallized from isopropanol. There is obtained 22.5 parts by weight of 1-[2-phenyl-2-chloroethyl]-1,2,4-triazole hydrochloride; m.p.: 178° C.

Workup

  1. temperaturethe mixture is refluxed until no more gas evolves
  2. temperatureAfter the mixture has been cooled
  3. filtrationfiltered
  4. washthe residue is washed with a small amount of chloroform
  5. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-41ccaab5fd5741a99ae8afbc11157e15
Source dataset
uspto-grants-1982_02
Patent number
US04315017

Reaction notes

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