1H-1,2,4-Triazole → 1-(3-Phenylpropyl)-1H-1,2,4-triazole

HRID 1447012Notes

Reaction equation

HRID 1447012 reaction equation
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.C(=O)([O-])[O-].[K+].[K+].[C:12]1([CH2:18][CH2:19][CH2:20]Br)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(#N)C>[C:12]1([CH2:18][CH2:19][CH2:20][N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 3

HCID 92571H-1,2,4-TriazoleHCID 11430Potassium CarbonateHCID 12503(3-Bromopropyl)benzene

Product 1

HCID 205285321-(3-Phenylpropyl)-1H-1,2,4-triazole

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 14 parts by weight of 1,2,4-triazole, 200 parts by weight of acetonitrile, 32 parts by weight of potassium carbonate and 40 parts by weight of 3-phenylpropyl bromide is stirred for 12 hours. The mixture is then filtered and the filtrate is concentrated. Distillation gives 25 parts by weight of pure 1-(3-phenylpropyl)-1,2,4-triazole; b.p. (0.013 mbar): 114°-116° C.

Workup

  1. filtrationThe mixture is then filtered
  2. concentrationthe filtrate is concentrated
  3. distillationDistillation

Sources & evidence

ORD record
ord-a8d69479e1bd405b8b207b23899cc8de
Source dataset
uspto-grants-1982_02
Patent number
US04315017

Reaction notes

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