Potassium Carbonate → HCID 12895170, compound

HRID 1447136Notes

Reaction equation

HRID 1447136 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[CH2:9][CH2:10][CH2:11][CH2:12][C:13]=2[C:14]=1[OH:15])=[O:5])[CH3:2].[CH2:16]([CH:18]1[O:20][CH2:19]1)Br.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:4]([C:6]1[NH:7][C:8]2[CH2:9][CH2:10][CH2:11][CH2:12][C:13]=2[C:14]=1[O:15][CH2:16][CH:18]1[O:20][CH2:19]1)([O:3][CH2:1][CH3:2])=[O:5]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 18430EpibromohydrinHCID 5961211H-Indole-2-carboxylic acid, 4,5,6,7-tetrahydro-3-hydroxy-, ethyl ester

Product 1

HCID 12895170HCID 12895170, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Using the method described in Example V, 130 g of 3-hydroxy-4,5,6,7-tetrahydroindole-2-carboxylic acid ethyl ester, 170 g of epibromohydrin and 172 g of anhydrous potassium carbonate in 500 ml of acetone give 165 g of 1-(2-carboethoxy-4,5,6,7-tetrahydro-indol-3-oxy)-2,3-epoxypropane, of melting point 102°-104° C.

Sources & evidence

ORD record
ord-be1b68054f5144a696c49986919436c7
Source dataset
uspto-grants-1982_02
Patent number
US04315939

Reaction notes

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