反应详情

A mixture of 10.93 g (40 mmol) of the above pyrimidine acid, 165 ml of N,N-dimethylacetamide, and 9.73 g of carbonyldiimidazole is stirred at 50° for 1 hr and for an additional 3 hrs at room temperature. The solid is filtered, washed with tetrahydrofuran and ether, and dried under vacuum overnight to give 13.97 g of 2-[4-(acetylamino)phenyl]-4-hydroxy-5-pyrimidine carboxylic acid imidazolide.

1. filtrationThe solid is filtered
2. washwashed with tetrahydrofuran and ether
3. customdried under vacuum overnight