反应详情

A mixture of 3.03 g (10 mmol) of the above pyrimidine acid 3.2 g (20 mmol) of carbonyldiimidazole, and 40 ml of dimethylformamide is stirred at 50° for 1 hr and at room temperature for 2 hrs. The reaction is diluted with 50 ml of ether and the solid filtered, washed with acetonitrile and ether, and dried to give 2.94 g of 2-[4-(methoxyacetylamino)phenyl]-4-hydroxy-5-pyrimidine carboxylic acid imidazolide.

1. filtrationthe solid filtered
2. washwashed with acetonitrile and ether
3. customdried