Hydrogen Peroxide → Isatoic Anhydride
Reaction equation
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[C:2]1=[O:3].[OH:12]O>C(O)=O>[C:6]12[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=1)[NH:1][C:2](=[O:12])[O:3][C:4]2=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Procedure
14.7 parts of isatin are suspended in 80 parts of formic acid. 20 parts of 30 percent strength hydrogen peroxide solution are added dropwise, with slight cooling. The mixture is then stirred for 60 minutes at 25° C., after which it is worked up in a conventional manner. 13.2 parts of isatoic anhydride are obtained; melting point 252°-253° C., with decomposition.
Sources & evidence
- ORD record
- ord-02800a23b2f74195aac508e43be208a9
- Source dataset
- uspto-grants-1982_02
- Patent number
- US04316020
Reaction notes
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