反应详情

A solution of 7-(benzhydrylideneamino)-3-(4-chlorophenyl)-2-isopropyl-chromen-4-one (5.72 g, 12 mmol) in tetrahydrofuran (150 ml) is treated with 2M HCl solution (150 ml) and allowed to stir at room temperature for 1 hour. The solution is basified with 17% ammonia solution (150 ml), and the mixture is extracted with ethyl acetate (3×200 ml). The organic extracts are combined, dried (MgSO4), filtered and concentrated to afford a yellow suspension. The suspension is triturated with hexanes to afford the title compound as a pale yellow solid, which is isolated by filtration and dried in vacuo overnight.

1. extractionthe mixture is extracted with ethyl acetate (3×200 ml)
2. dry with materialdried (MgSO4)
3. filtrationfiltered
4. concentrationconcentrated
5. customto afford a yellow suspension
6. customThe suspension is triturated with hexanes