Hydrochloric Acid → HCID 20384409, compound

HRID 1447646Notes

Reaction equation

HRID 1447646 reaction equation
[C:1]1([N:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:8]([CH2:10][C:11]([O:13]CC)=[O:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].Cl>O.C(O)C>[C:1]1([N:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:8]([CH2:10][C:11]([OH:13])=[O:12])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 23339646HCID 23339646, compound

Product 1

HCID 20384409HCID 20384409, compoundYield 98.9%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

22.6 g (0.08 mol) of ethyl N,N-diphenylcarbamoylacetate (m.p.=75°-76° C.) are added to a solution of 5.6 g(0.1 mol) of KOH in a mixture of 50 ml of water and 25 ml of ethanol. The mixture is heated to 40° C. with agitation until dissolution is complete (that is, for about 1 hour) and agitation is continued for two hours. Acidification is then carried out with 3 N HCl, followed by drying without heat, washing with water and drying.20.2 g (yield: 98%) of N,N-diphenylcarbamoylacetic acid (m.p.=126°-127° C.) are obtained.

Workup

  1. wait) and agitation is continued for two hours
  2. customby drying
  3. temperaturewithout heat
  4. washwashing with water
  5. customdrying

Sources & evidence

ORD record
ord-3f06285c21134b48a36991f56e3d9e91
Source dataset
uspto-grants-1979_12
Patent number
US04177290

Reaction notes

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