Dicyclohexylcarbodiimide → HCID 53865071, compound

HRID 1447647Notes

Reaction equation

HRID 1447647 reaction equation
[C:1]1([N:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]([CH2:10][C:11]([OH:13])=O)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:20][CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1.C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[C:14]1([N:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8](=[O:9])[CH2:10][C:11]([NH:20][CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)=[O:13])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 4082852-MorpholinoethylamineHCID 20384409HCID 20384409, compound

Product 1

HCID 53865071HCID 53865071, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 13 g (0.05 mol) of N,N-diphenylcarbamoylacetic acid and 7.1 g (0.055 mol) of N-(2-aminoethyl)morpholine in 120 ml of methylene chloride is refluxed with agitation. A solution of 11 g (0.055 mol) of dicyclohexylcarbodiimide in 30 ml of CH2Cl2 is slowly added and the mixture is maintained under reflux for 3 hours.

Workup

  1. temperaturethe mixture is maintained
  2. temperatureunder reflux for 3 hours

Sources & evidence

ORD record
ord-ea69a5ed8a12469c845113ba8e3e56a7
Source dataset
uspto-grants-1979_12
Patent number
US04177290

Reaction notes

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