Butylhydrazine → 6-phenyl-2-(2-hydroxyhexyl)-4-hydroxy-4,5-dihydropyridazine-3(2H)-one
反応式
[C:1]([CH2:9][CH:10]([OH:14])[C:11]([OH:13])=O)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:15]([CH2:17][CH:18]([OH:23])[CH2:19][CH2:20][CH2:21][CH3:22])[NH2:16].N(CC(O)C)N.C(C(C)C(O)C(O)=O)(=O)C1C=CC=CC=1.C(NN)CCC.N(CC(O)CC)N>>[C:2]1([C:1]2[CH2:9][CH:10]([OH:14])[C:11](=[O:13])[N:15]([CH2:17][CH:18]([OH:23])[CH2:19][CH2:20][CH2:21][CH3:22])[N:16]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
7
反応物 6
生成物 1
実験手順
When the above procedure is carried out using equivalent amounts of 3-benzoyl-2-hydroxy-propionic acid and 1-hydrazino-2-hexanol or 3-benzoyl-2-hydroxy-propionic acid and 1-hydrazino-2-propanol or 3-benzoyl-2-hydroxy-3-methyl-propionic acid and butyl hydrazine in place of the 3-benzoyl-2-hydroxy-propionic acid and 1-hydrazino-2-butanol used therein, there is obtained 6-phenyl-2-(2-hydroxyhexyl)-4-hydroxy-4,5-dihydropyridazine-3(2H)-one; 6-phenyl-2-(2-hydroxypropyl)-4-hydroxy-4,5-dihydropyridazin-3(2H)-one; or 2-butyl-4,5-dihydro-4-hydroxy-5-methyl-6-phenylpyridazin-3(2H)-one (m.p. 129°-155° C.), respectively.
出典と根拠
- ORDレコード
- ord-234728425da640fab80f509e2282d68d
- 出典データセット
- uspto-grants-1979_12
- 特許番号
- US04177273
反応ノート
読み込み中…