反应详情

A solution of tetrahydro-4H-thiopyran-4-one (10.0 g, 0.086 mole) and 4-chlorobenzaldehyde (24.0 g, 0.172 mole) in 60 ml ethanol is treated with 6 ml of concentrated HCl and heated at reflux temperature for 2 hours. Upon cooling, 10 g of product is collected. Concentration of the mother liquor and washings to the original volume and adding additional concentrated HCl (4 ml) gives another 12 g of product. The combined crude material, recrystallized from CHCl3 /EtOH gives 15 g of product, m.p. 163°-165°.

1. temperatureheated
2. temperatureat reflux temperature for 2 hours
3. temperatureUpon cooling
4. custom10 g of product is collected
5. additionConcentration of the mother liquor and washings to the original volume and adding additional concentrated HCl (4 ml)