反应详情

5.7 gm of 4,4-dimethyl-2H,4H-isoquinoline-1,3-dione and 3.3 gm of 1-chloro-2-methylmercapto-ethane were added to a solution of 0.7 gm of sodium in 200 ml of isopropanol. After refluxing the mixture for 3 hours the solvent was removed in vacuo, and the residue was taken up in water and chloroform. The separated organic phase was worked up as described in Example 1. Yield: 7 gm (88.6% of theory).

1. temperatureAfter refluxing the mixture for 3 hours the solvent
2. customwas removed in vacuo