Methanethiol → HCID 54432291, compound

HRID 1448040Notes

Reaction equation

HRID 1448040 reaction equation
[CH3:1][SH:2].[Na].[CH3:4][C:5]1([CH3:19])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](=[O:15])[N:7]([CH2:16]Cl)[C:6]1=[O:18]>C(O)C>[CH3:4][C:5]1([CH3:19])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](=[O:15])[N:7]([CH2:16][S:2][CH3:1])[C:6]1=[O:18]

Participants

5

Reactant 3

HCID 878MethanethiolHCID 5360545SodiumHCID 20381220HCID 20381220, compound

Product 1

HCID 54432291HCID 54432291, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

1.92 gm of methylmercaptan were added to an ice-cooled solution of 0.92 gm of sodium in 50 ml of ethanol. A suspension of 8.6 gm of 4,4-dimethyl-2-chloromethyl-2H,4H-isoquinoline-1,3-dione in 100 ml of ethanol was added, and the mixture was refluxed for 45 minutes. Thereafter, the reaction mixture was evaporated, the residue was triturated with water, filtered, the filter cake was recrystallized from isopropanol.

Workup

  1. additionwas added
  2. temperaturethe mixture was refluxed for 45 minutes
  3. customThereafter, the reaction mixture was evaporated
  4. customthe residue was triturated with water
  5. filtrationfiltered
  6. customthe filter cake was recrystallized from isopropanol

Sources & evidence

ORD record
ord-af28bf8bcbbb4d7c90b338a1f7c13972
Source dataset
uspto-grants-1979_12
Patent number
US04179508

Reaction notes

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