Ammonia → HCID 178431931, compound

HRID 1448397Notes

Reaction equation

HRID 1448397 reaction equation
[N+](C1C=CC(O[C:9]([CH:11]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:12]([NH:14][CH:15]2[C:28](=[O:29])[N:17]3[CH:18]([C:23]4[NH:27][N:26]=[N:25][N:24]=4)[C:19]([CH3:22])([CH3:21])[S:20][C@H:16]23)=[O:13])=[O:10])=CC=1)([O-])=O.C([N:40](CC)CC)C.C(Cl)(Cl)Cl.N>CO>[C:9]([CH:11]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:12]([NH:14][CH:15]1[C:28](=[O:29])[N:17]2[CH:18]([C:23]3[NH:27][N:26]=[N:25][N:24]=3)[C:19]([CH3:22])([CH3:21])[S:20][C@H:16]12)=[O:13])(=[O:10])[NH2:40]

Participants

6

Reactant 4

HCID 222AmmoniaHCID 6212ChloroformHCID 8471TriethylamineHCID 178431934HCID 178431934, compound

Product 1

HCID 178431931HCID 178431931, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of 523 mg. (0.001 mole) of 6-(2-[p-nitrophenoxycarbonyl]-2-phenylacetamido)-2,2-dimethyl-3-(5-tetrazolyl)penam and 101 mg of triethylamine in 50 ml. of chloroform is added 1 ml of a 1 M solution of ammonia in methanol, at -30° C. Stirring is continued for 4 hours without external cooling and then evaporation in vacuo leaves the crude product as its triethylamine salt.

Workup

  1. customat -30° C
  2. temperaturewithout external cooling
  3. customevaporation in vacuo

Sources & evidence

ORD record
ord-b96a8a33e039452faab16f55460cba44
Source dataset
uspto-grants-1979_12
Patent number
US04179511

Reaction notes

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