Bromoacetic Acid → (2-Formyl-1H-pyrrol-1-yl)acetic acid

HRID 1448571Notes

Reaction equation

Br[CH2:2][C:3]([OH:5])=[O:4].[NH:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[CH:11]=[O:12]>>[CH:11]([C:7]1[N:6]([CH2:2][C:3]([OH:5])=[O:4])[CH:10]=[CH:9][CH:8]=1)=[O:12]

Participants

Reactant 2

HCID 6227Bromoacetic Acid

HCID 13854Pyrrole-2-carboxaldehyde

Product 1

HCID 12459347(2-Formyl-1H-pyrrol-1-yl)acetic acid

Procedure

In a similar manner, when the halogenated alkanoic acids listed in Table 1 are substituted for bromoacetic acid and reacted with pyrrole-2-carboxaldehyde, the products listed in Table 1 are obtained.

Workup

customare obtained

Sources & evidence

ORD record: ord-b1e682f3880f41beb57eb6d4b8cac8b8
Source dataset: uspto-grants-1979_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04180660

Reaction notes

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