反应详情

The sodium salt of 3-[(acetyloxy)methyl]-7-[[(2-formyl-1-pyrryl)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2.5 mmole) in 50 ml of dimethylformamide (DMF) is treated at room temperature with 2.5 mmole of N-chloromethyl-N-methylurethane for 1 hour. The mixture is carefully poured into ice water and the precipitated solid is removed by filtration and is then washed with water. The filtered solid is dissolved in ethyl acetate and washed with aqueous sodium bicarbonate and then with water. The organic layer is dried over magnesium sulfate, filtered and evaporated to dryness to give the title compound.

1. customthe precipitated solid is removed by filtration
2. washis then washed with water
3. dissolutionThe filtered solid is dissolved in ethyl acetate
4. washwashed with aqueous sodium bicarbonate
5. dry with materialThe organic layer is dried over magnesium sulfate
6. filtrationfiltered
7. customevaporated to dryness