Water → HCID 13405244, compound

HRID 1448967Notes

Reaction equation

HRID 1448967 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[O:9][CH:10]([C:13](N)=[O:14])[CH2:11][O:12][C:7]=2[CH:6]=[CH:5][CH:4]=1.[OH2:16]>Cl>[CH3:1][O:2][C:3]1[C:8]2[O:9][CH:10]([C:13]([OH:14])=[O:16])[CH2:11][O:12][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 962WaterHCID 10656007HCID 10656007, compound

Product 1

HCID 13405244HCID 13405244, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

8-Methoxy-1,4-benzodioxan-2-carboxamide (2.41 g.) in 50% hydrochloric acid (35 ml.) was stirred at 100° C. for 1 hour. The resulting solution was cooled, diluted with water (200 ml.), extracted with chloroform (3×100 ml.) then the extracts dried (MgSO4) and evaporated in vacuo. The solid residue (1.8 g.) was recrystallized from water (m.p. 75°-78° C.) then from ethyl acetate/hexane to give 8-methoxy-1,4-benzodioxan-2-carboxylic acid, m.p. 131°-132° C.

Workup

  1. temperatureThe resulting solution was cooled
  2. extractionextracted with chloroform (3×100 ml.)
  3. dry with materialthe extracts dried (MgSO4)
  4. customevaporated in vacuo
  5. customThe solid residue (1.8 g.) was recrystallized from water (m.p. 75°-78° C.)

Sources & evidence

ORD record
ord-7cc2cab26b074c9e9a0fe25be810ff22
Source dataset
uspto-grants-1980_02
Patent number
US04188390

Reaction notes

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