4-Bromotoluene → 1-Benzyl-4-(4-methylphenyl)piperidin-4-ol

HRID 1448976Notes

Reaction equation

HRID 1448976 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=1.[CH2:9]([N:16]1[CH2:21][CH2:20][C:19](=[O:22])[CH2:18][CH2:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH2:9]([N:16]1[CH2:21][CH2:20][C:19]([OH:22])([C:2]2[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=2)[CH2:18][CH2:17]1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 78054-BromotolueneHCID 192201-Benzyl-4-piperidone

Product 1

HCID 1986081-Benzyl-4-(4-methylphenyl)piperidin-4-ol

Procedure

The starting material can be produced in the following manner: In a manner analogous to that described in Example 6, 100 g of p-bromotoluene and 110 g of N-benzyl-4-piperidone are reacted to give N-benzyl-4-hydroxy-4-(4-methylphenyl)-piperidine, b.p.0.05 =185°.

Workup

  1. customThe starting material can be produced in the following manner
  2. customare reacted

Sources & evidence

ORD record
ord-3d70023131c940438004525c06852faf
Source dataset
uspto-grants-1980_02
Patent number
US04188396

Reaction notes

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