1,2-Dibromopropane → HCID 20374797, compound

HRID 1448990Notes

Reaction equation

HRID 1448990 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10](=[S:20])[NH:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.Br[CH2:22][CH:23](Br)[CH3:24]>CN(C)C=O>[CH2:22]([S:20][C:10]1[NH:11][C:12]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[N:9]=1)[CH:23]([S:20][C:10]1[NH:11][C:12]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[N:9]=1)[CH3:24]

Participants

4

Reactant 2

HCID 65531,2-DibromopropaneHCID 13508053HCID 13508053, compound

Product 1

HCID 20374797HCID 20374797, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 4,5-bis(4-fluorophenyl)-1H-imidazole-2-thione (10 g, 0.035 mol) and 1,2-dibromopropane (3.5 g, 0.017 mol) in N,N-dimethylformamide (25 ml) was refluxed for two hours, then cooled. The precipitate was collected, treated with hot chloroform and recrystallized from isopropanol to give the title compound as its dihydrobromide salt, m.p. 243°-245°.

Workup

  1. temperaturecooled
  2. customThe precipitate was collected
  3. additiontreated with hot chloroform
  4. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-2dbf004f8de744f8b60a04744b428035
Source dataset
uspto-grants-1980_02
Patent number
US04188397

Reaction notes

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