HRID1449015

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID222

Ammonia gas

H3N

HCID541

4-Nitrobenzaldehyde

C7H5NO3

HCID701239

Ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-oxobutanoate

C14H13NO5

PRODUCTS

生成物

结构：CCOC(=O)C1=C(CN2C(=O)c3ccccc3C2=O)NC(CN2C(=O)c3ccccc3C2=O)=C(C(=O)OCC)C1c1ccc([N+](=O)[O-])cc1

HCID70591792

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

7.5 g of 4-nitrobenzaldehyde, 28 g of γ-phthalimidoacetoacetic acid ethyl ester and 7 ccs of concentrated ammonia in 120 ccs of ethanol are heated to the boil under reflux for 60 hours and the product is filtered off after cooling on ice.

WORKUP

后处理

temperatureunder reflux for 60 hours
filtrationthe product is filtered off
temperatureafter cooling on ice

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5205feddbabe449fa1be8fca1de6508a
来源数据集: uspto-grants-1980_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04188395
来源说明: uspto-grants-1980_02

反应 SMILES

[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH2:12]([O:14][C:15](=[O:31])[CH2:16][C:17]([CH2:19][N:20]1[C:24](=[O:25])[C:23]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:22]2[C:21]1=[O:30])=O)[CH3:13].[NH3:32]>C(O)C>[CH2:12]([O:14][C:15]([C:16]1[CH:8]([C:7]2[CH:10]=[CH:11][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[C:16]([C:15]([O:14][CH2:12][CH3:13])=[O:31])=[C:17]([CH2:19][N:20]2[C:21](=[O:30])[C:22]3=[CH:29][CH:28]=[CH:27][CH:26]=[C:23]3[C:24]2=[O:25])[NH:32][C:17]=1[CH2:19][N:20]1[C:24](=[O:25])[C:23]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:22]2[C:21]1=[O:30])=[O:31])[CH3:13]