Ammonia → HCID 70591792, compound

HRID 1449015Notes

Reaction equation

HRID 1449015 reaction equation
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH2:12]([O:14][C:15](=[O:31])[CH2:16][C:17]([CH2:19][N:20]1[C:24](=[O:25])[C:23]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:22]2[C:21]1=[O:30])=O)[CH3:13].[NH3:32]>C(O)C>[CH2:12]([O:14][C:15]([C:16]1[CH:8]([C:7]2[CH:10]=[CH:11][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[C:16]([C:15]([O:14][CH2:12][CH3:13])=[O:31])=[C:17]([CH2:19][N:20]2[C:21](=[O:30])[C:22]3=[CH:29][CH:28]=[CH:27][CH:26]=[C:23]3[C:24]2=[O:25])[NH:32][C:17]=1[CH2:19][N:20]1[C:24](=[O:25])[C:23]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:22]2[C:21]1=[O:30])=[O:31])[CH3:13]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 5414-NitrobenzaldehydeHCID 701239Ethyl 4-(1,3-dioxoisoindolin-2-YL)-3-oxobutanoate

Product 1

HCID 70591792HCID 70591792, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7.5 g of 4-nitrobenzaldehyde, 28 g of γ-phthalimidoacetoacetic acid ethyl ester and 7 ccs of concentrated ammonia in 120 ccs of ethanol are heated to the boil under reflux for 60 hours and the product is filtered off after cooling on ice.

Workup

  1. temperatureunder reflux for 60 hours
  2. filtrationthe product is filtered off
  3. temperatureafter cooling on ice

Sources & evidence

ORD record
ord-5205feddbabe449fa1be8fca1de6508a
Source dataset
uspto-grants-1980_02
Patent number
US04188395

Reaction notes

Loading…