Potassium Carbonate → 9-(2,6-Dichlorobenzyl)-6-methylaminopurine

HRID 1449147Notes

Reaction equation

HRID 1449147 reaction equation
[CH3:1][NH:2][C:3]1[N:11]=[CH:10][N:9]=[C:8]2[C:4]=1[NH:5][CH:6]=[N:7]2.C(=O)([O-])[O-].[K+].[K+].[Cl:18][C:19]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:20]=1[CH2:21]Cl>CN(C)C(=O)C>[Cl:18][C:19]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:20]=1[CH2:21][N:7]1[CH:6]=[N:5][C:4]2[C:8]1=[N:9][CH:10]=[N:11][C:3]=2[NH:2][CH3:1]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 67955N6-MethyladenineHCID 748322,6-Dichlorobenzyl chloride

Product 1

HCID 144173839-(2,6-Dichlorobenzyl)-6-methylaminopurineYield 62%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a procedure analogous to that of Example 9, by using 1.49 g of 6-methylaminopurine, 1.38 g of potassium carbonate, 50 ml of N,N-dimethylacetamide and 3.92 g of 2,6-dichlorobenzyl chloride, there was obtained 1.9 g of 9-(2,6-dichlorobenzyl)-6-methylaminopurine as colorless needles (yield: 62%), m.p. 219°-220° C. NMR spectrum of this product is identical with that of the corresponding compound synthesized in Example 2.

Sources & evidence

ORD record
ord-cb69118198f34181a2a0e1c42bbf99e2
Source dataset
uspto-grants-1980_02
Patent number
US04189485

Reaction notes

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