Potassium Carbonate → HCID 20350134, compound

HRID 1449149Notes

Reaction equation

HRID 1449149 reaction equation
[CH2:1]([NH:3][C:4]1[N:12]=[CH:11][N:10]=[C:9]2[C:5]=1[NH:6][CH:7]=[N:8]2)[CH3:2].C(=O)([O-])[O-].[K+].[K+].[Cl:19][C:20]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:21]=1[CH2:22]Cl>CN(C)C(=O)C>[Cl:19][C:20]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:21]=1[CH2:22][N:8]1[CH:7]=[N:6][C:5]2[C:9]1=[N:10][CH:11]=[N:12][C:4]=2[NH:3][CH2:1][CH3:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1086751-Chloro-2-(chloromethyl)-3-fluorobenzeneHCID 1304107116370-43-7

Product 1

HCID 20350134HCID 20350134, compoundYield 34.1%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a procedure analogous to that of Example 9, by using 1.63 g of 6-ethylaminopurine, 1.38 g of potassium carbonate, 50 ml of N,N-dimethylacetamide and 3.58 g of 2-chloro-6-fluorobenzyl chloride, there was obtained 1.04 g of 9-(2-chloro-6-fluorobenzyl)-6-ethylaminopurine as colorless needles (yield: 34%), m.p. 175°-176° C.

Sources & evidence

ORD record
ord-4c6cf12abde047229de9b891fbbb35fb
Source dataset
uspto-grants-1980_02
Patent number
US04189485

Reaction notes

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