Potassium Carbonate → HCID 14855343, compound

HRID 1449150Notes

Reaction equation

HRID 1449150 reaction equation
[CH2:1]([NH:4][C:5]1[N:13]=[CH:12][N:11]=[C:10]2[C:6]=1[NH:7][CH:8]=[N:9]2)[CH2:2][CH3:3].C(=O)([O-])[O-].[K+].[K+].[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:22]=1[CH2:23]Cl>CN(C)C(=O)C>[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:22]=1[CH2:23][N:9]1[CH:8]=[N:7][C:6]2[C:10]1=[N:11][CH:12]=[N:13][C:5]=2[NH:4][CH2:1][CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1086751-Chloro-2-(chloromethyl)-3-fluorobenzeneHCID 2155040HCID 2155040, compound

Product 1

HCID 14855343HCID 14855343, compoundYield 59.2%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a procedure analogous to that of Example 9, by using 1.77 g of 6-n-propylaminopurine, 1.38 g of potassium carbonate, 50 ml of N,N-dimethylacetamide and 3.58 g of 2-chloro-6-fluorobenzyl chloride, there was obtained 1.89 g of 9-(2-chloro-6-fluorobenzyl)-6-n-propylaminopurine as colorless needles (yield: 59%), m.p. 166°-167° C.

Sources & evidence

ORD record
ord-cd8322d04aae4f67a58f1c126a09a38a
Source dataset
uspto-grants-1980_02
Patent number
US04189485

Reaction notes

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