Potassium Carbonate → HCID 20350126, compound

HRID 1449151Notes

Reaction equation

HRID 1449151 reaction equation
[CH2:1]([NH:4][C:5]1[N:13]=[CH:12][N:11]=[C:10]2[C:6]=1[NH:7][CH:8]=[N:9]2)[CH:2]=[CH2:3].C(=O)([O-])[O-].[K+].[K+].[Cl:20][C:21]1[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:22]=1[CH2:23]Cl>CN(C)C(=O)C>[CH2:1]([NH:4][C:5]1[N:13]=[CH:12][N:11]=[C:10]2[C:6]=1[N:7]=[CH:8][N:9]2[CH2:23][C:22]1[C:25]([F:29])=[CH:26][CH:27]=[CH:28][C:21]=1[Cl:20])[CH:2]=[CH2:3]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1086751-Chloro-2-(chloromethyl)-3-fluorobenzeneHCID 1558420N-(Prop-2-en-1-yl)-7H-purin-6-amine

Product 1

HCID 20350126HCID 20350126, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a procedure analogous to that of Example 9, by using 1.75 g of 6-allylaminopurine, 1.38 g of potassium carbonate, 50 ml of N,N-dimethylacetamide and 3.58 g of 2-chloro-6-fluorobenzyl chloride, there was obtained 1.84 g of 6-allylamino-9-(2-chloro-6-fluorobenzyl)purine as colorless needles (yield: 58%), m.p. 163°-164° C.

Sources & evidence

ORD record
ord-c76fb9ec569a47ba8fdd3ac680b7dd40
Source dataset
uspto-grants-1980_02
Patent number
US04189485

Reaction notes

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