Tiflamizole → HCID 86736848, compound

HRID 1449398Notes

Reaction equation

HRID 1449398 reaction equation
C[O-].[Na+].[Na:4].[F:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]([S:24]([C:27]([F:32])([F:31])[CH:28]([F:30])[F:29])(=[O:26])=[O:25])[NH:15][C:16]=2[C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)=[CH:8][CH:7]=1>CCOCC>[Na:4].[F:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:14]([S:24]([C:27]([F:32])([F:31])[CH:28]([F:29])[F:30])(=[O:25])=[O:26])[NH:15][C:16]=2[C:17]2[CH:18]=[CH:19][C:20]([F:23])=[CH:21][CH:22]=2)=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 44188TiflamizoleHCID 5360545SodiumHCID 10942334Sodium Methoxide

Product 1

HCID 86736848HCID 86736848, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 4,5l -bis(4-fluorophenyl)-2-(1,1,2,2-tetrafluoroethylsulfonyl)imidazole (5.0 g., 0.0119 mole), sodium methoxide (0.6 g., 0.0111 mole) and ether (300 ml.) is stirred overnight at room temperature. The solid is collected and washed with ether to give 2.1 g. of the sodium salt of 4,5-bis(4-fluorophenyl)-2-(1,1,2,2-tetrafluoroethylsulfonyl)imidazole, m.p. 290°-292°.

Workup

  1. customThe solid is collected
  2. washwashed with ether
  3. customto give 2.1 g

Sources & evidence

ORD record
ord-bf450b271feb4328b14caf405da01dd2
Source dataset
uspto-grants-1980_02
Patent number
US04190666

Reaction notes

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