Ethanol → HCID 21855102, compound

HRID 1449443Notes

Reaction equation

[H-].[Na+].Cl[C:4]1[CH:9]=[C:8]([CH3:10])[N:7]=[C:6]([S:11][CH3:12])[N:5]=1.[CH2:13]([OH:15])[CH3:14]>>[CH2:13]([O:15][C:4]1[CH:9]=[C:8]([CH3:10])[N:7]=[C:6]([S:11][CH3:12])[N:5]=1)[CH3:14]

Participants

Reactant 3

HCID 702Ethanol

HCID 24758Sodium hydride

HCID 2411634-Chloro-6-methyl-2-(methylthio)pyrimidine

Product 1

HCID 21855102HCID 21855102, compound

Procedure

To sodium hydride (2.75 g (60% in mineral oil), 0.046×1.5 mmol) dissolved in ethanol (20 ml), 4-chloro-6-methyl-2-methylmercaptopyrimidine (Compound IV-7) (8.0 g, 0.046 mmol) was added and the solution was stirred for about 1 hour at room temperature.

Sources & evidence

ORD record: ord-482b302b29ce43229a7318e98ca7feb3
Source dataset: uspto-grants-1997_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05599770

Reaction notes

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