Potassium Carbonate → HCID 19978298, compound

HRID 1449491Notes

Reaction equation

HRID 1449491 reaction equation
[N:1]1([C:7]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[S:9][N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[CH2:17][CH2:18][CH2:19][CH2:20][N:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][C:22]1=[O:31].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[S:9]1[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:7]([N:1]2[CH2:6][CH2:5][N:4]([CH2:17][CH2:18][CH2:19][CH2:20][N:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH:24]=[CH:23][C:22]3=[O:31])[CH2:3][CH2:2]2)=[N:8]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27721443-(1-Piperazinyl)-1,2-benzisothiazoleHCID 19978296HCID 19978296, compound

Product 1

HCID 19978298HCID 19978298, compoundYield 81.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3-(1-piperazinyl)-1,2-benzisothiazole (0.44 g, 2.0 mmoles), 1-(4-bromobutyl)-2(1H)-quinolinone (0.56 g, 2.0 mmoles) and potassium carbonate (0.33 g, 2.4 mmoles) were suspended in 4 ml of dimethylformamide, and the mixture was stirred at room temperature for 12 hours. Insolubles were removed by filtration, and the solvent was removed under reduced pressure. The residue was purified by chromatography on a silica gel column to give 0.68 g (yield 80%) of the title compound as an oil.

Workup

  1. customInsolubles were removed by filtration
  2. customthe solvent was removed under reduced pressure
  3. customThe residue was purified by chromatography on a silica gel column

Sources & evidence

ORD record
ord-95aec8db99a3424ca6e1ab02a9532019
Source dataset
uspto-grants-1997_02
Patent number
US05599815

Reaction notes

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