HCID 19978182, compound → HCID 67715282, compound

HRID 1449531Notes

Reaction equation

HRID 1449531 reaction equation
[ClH:1].[CH3:2][C:3]1[N:7]2[CH2:8][C:9]([CH3:13])([CH3:12])[CH2:10][N:11]=[C:6]2[S:5][C:4]=1[C:14]([O:16]C(C)(C)C)=[O:15]>Cl>[ClH:1].[CH3:2][C:3]1[N:7]2[CH2:8][C:9]([CH3:12])([CH3:13])[CH2:10][N:11]=[C:6]2[S:5][C:4]=1[C:14]([OH:16])=[O:15]

Participants

3

Reactant 1

HCID 19978182HCID 19978182, compound

Product 1

HCID 67715282HCID 67715282, compoundYield 78.9%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

In 100 ml of 2N hydrochloric acid was suspended 2.0 g of tert-butyl 3,6,6-trimethyl-6,7-dihydro-5H-thiazolo[3,2-a]-pyrimidine-2-carboxylate hydrochloride obtained in Example 119, followed by stirring at room temperature for 7 hours. The precipitated crystals were collected by filtration and washed with diethylether and acetone to obtain 1.3 g of the titled compound.

Workup

  1. filtrationThe precipitated crystals were collected by filtration
  2. washwashed with diethylether and acetone

Sources & evidence

ORD record
ord-1af3256b4b78422996db69c62e6e0a43
Source dataset
uspto-grants-1997_02
Patent number
US05599813

Reaction notes

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