Sodium Methoxide → HCID 70058796, compound

HRID 1449541Notes

Reaction equation

HRID 1449541 reaction equation
C[O:2][C:3](=O)[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:5]=1[S:14](=[O:22])(=[O:21])[NH:15][CH2:16][C:17]([O:19][CH3:20])=[O:18].C[O-].[Na+]>CN(C=O)C.Cl>[CH3:20][O:19][C:17]([C:16]1[NH:15][S:14](=[O:22])(=[O:21])[C:5]2[CH:6]=[C:7]([O:12][CH3:13])[C:8]([O:10][CH3:11])=[CH:9][C:4]=2[C:3]=1[OH:2])=[O:18]

Participants

5

Reactant 2

HCID 10942334Sodium Methoxide2×HCID 57013520HCID 57013520, compound

Product 1

HCID 70058796HCID 70058796, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 6228DimethylformamideSolvent

Procedure

To a solution of 4,5-dimethoxy-2-(methoxycarbonylmethyl-sulfamoyl)-benzoic acid methyl ester (0.555 g, 1.60 mmol) in dry DMF (3 mL) was added dry and freshly prepared sodium methoxide (0.345 g, 6.39 mmol). A red colour was generated upon the addition of the sodium methoxide. The mixture was stirred for 45 minutes, and then diluted with 1N HCl (100 mL). The pale yellow solid that precipitated was collected and washed with water (0.341 g, 68%);

Workup

  1. customdry
  2. customThe pale yellow solid that precipitated was collected
  3. washwashed with water (0.341 g, 68%)

Sources & evidence

ORD record
ord-8367bd722e5b4ce28c7795bcd90e7664
Source dataset
uspto-grants-1997_02
Patent number
US05599811

Reaction notes

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