Hydrogen Peroxide → HCID 15335357, compound

HRID 1449633Notes

Reaction equation

HRID 1449633 reaction equation
[F:1][C:2]([C:5]1[NH:6][C:7]2[C:12]([C:13]=1[S:14][C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=[CH:9][CH:8]=2)([F:4])[F:3].[OH:19]O>C(O)(=O)C>[F:3][C:2]([F:1])([F:4])[C:5]1[NH:6][C:7]2[C:12]([C:13]=1[S:14]([C:15]([F:16])([F:17])[F:18])=[O:19])=[CH:11][CH:10]=[CH:9][CH:8]=2

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 15335350HCID 15335350, compound

Product 1

HCID 15335357HCID 15335357, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 2-(trifluoromethyl -3-[(trifluoromethyl)thio]indole (0.96 g, 3.36 mmole) and 30% hydrogen peroxide (1.15 mL, 10.1 mmole) in acetic acid is heated at 50° C. for 16 hours, cooled to room temperature, poured onto water and filtered. The filter cake is air-dried to give the title product as a colorless solid, 0.535 g (50% yield), mp 183°-185° C., identified by IR, 1HNMR, 13CNMR, 19FNMR and mass spectral analyses.

Workup

  1. temperaturecooled to room temperature
  2. additionpoured onto water
  3. filtrationfiltered
  4. customThe filter cake is air-dried

Sources & evidence

ORD record
ord-a3ed060b04d440168d2c5f2f4c0e2ad3
Source dataset
uspto-grants-1997_02
Patent number
US05599832

Reaction notes

Loading…