Thionyl Chloride → HCID 15334936, compound

HRID 1449636Notes

Reaction equation

HRID 1449636 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([Cl:11])[CH:10]=1)[NH:7][C:6]([C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=1)=[CH:5]2.S(Cl)([Cl:21])=O>O1CCCC1>[Cl:21][C:5]1[C:4]2[C:8](=[C:9]([Cl:11])[CH:10]=[C:2]([Cl:1])[CH:3]=2)[NH:7][C:6]=1[C:12]1[CH:13]=[CH:14][C:15]([Cl:18])=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 15334935HCID 15334935, compound

Product 1

HCID 15334936HCID 15334936, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(1.0 g, 3.38 mmole) A solution of 5,7-dichloro-2-(p-chlorophenyl)-indole(in tetrahydrofuran is treated dropwise with 1.0 mL of thionyl chloride, stirred for 16 hours at room temperature, poured over ice and filtered. The filtercake is air-dried to afford the title product as a yellow solid, 0.85 g (76% yield), mp 148°-149° C., identified by IR, 1HNMR and elemental analyses.

Workup

  1. additionpoured over ice
  2. filtrationfiltered
  3. customThe filtercake is air-dried

Sources & evidence

ORD record
ord-b7f15e31d354448b85aca017b630bd68
Source dataset
uspto-grants-1997_02
Patent number
US05599832

Reaction notes

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