Isopropyl iodide → HCID 67721451, compound

HRID 1449640Notes

Reaction equation

HRID 1449640 reaction equation
[OH:1][C@H:2]1[CH2:15][C@@H:14]([OH:16])[C@H:13](/[CH:17]=[CH:18]/[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C@H:3]1[CH2:4]/[CH:5]=[CH:6]\[CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11].[CH2:25]1[CH2:35]CN2C(=NCCC2)C[CH2:26]1.C(I)(C)C>C(#N)C>[CH:25]([O:11][C:10](=[O:12])[CH2:9][CH2:8][CH2:7]/[CH:6]=[CH:5]\[CH2:4][C@@H:3]1[C@@H:13](/[CH:17]=[CH:18]/[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C@H:14]([OH:16])[CH2:15][C@@H:2]1[OH:1])([CH3:35])[CH3:26]

Participants

5

Reactant 3

HCID 6362Isopropyl iodideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 9820288HCID 9820288, compound

Product 1

HCID 67721451HCID 67721451, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound 8 was obtained as a colorless oil (36 mg, 95%), following a procedure similar to that disclosed in Example 5 except that the compound 6 obtained above (33 mg, 0.1 mmole) was dissolved in acetonitrile (1 ml), and 1,8-diazabicyclo[5.4.0]-7-undecene (40 μl, 0.3 mmole) and then isopropyl iodide (0.19 μl, 1 mmole) were added thereto.

Workup

  1. customobtained above (33 mg, 0.1 mmole)

Sources & evidence

ORD record
ord-95265a8d8af8462aad0a36d5c4179237
Source dataset
uspto-grants-1997_02
Patent number
US05599837

Reaction notes

Loading…