Isopropyl iodide → HCID 67721476, compound

HRID 1449643Notes

Reaction equation

HRID 1449643 reaction equation
[OH:1][C@H:2]1[CH2:15][C@@H:14]([OH:16])[C@H:13]([CH2:17][CH2:18]/[CH:19]=[CH:20]/[CH2:21][CH2:22][CH2:23][CH3:24])[C@H:3]1[CH2:4]/[CH:5]=[CH:6]\[CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11].[CH2:25]1[CH2:35]CN2C(=NCCC2)C[CH2:26]1.C(I)(C)C>C(#N)C>[CH:25]([O:11][C:10](=[O:12])[CH2:9][CH2:8][CH2:7]/[CH:6]=[CH:5]\[CH2:4][C@@H:3]1[C@@H:13]([CH2:17][CH2:18]/[CH:19]=[CH:20]/[CH2:21][CH2:22][CH2:23][CH3:24])[C@H:14]([OH:16])[CH2:15][C@@H:2]1[OH:1])([CH3:35])[CH3:26]

Participants

5

Reactant 3

HCID 6362Isopropyl iodideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 67721081HCID 67721081, compound

Product 1

HCID 67721476HCID 67721476, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The compound 28' obtained obove (87 mg, 0.237 mmole) was dissolved in acetonitrile (2 ml), and 1,8-diazabicyclo[5.4.0]-7-undecene (0.716 ml, 4.8 mmole) and isopropyl iodide (0.24 ml, 2.4 mmole) were added thereto and the mixture was stirred at room temperature for 16 hours. Then, the reaction mixture was treated following the procedure similar to that of Example 5, to yield 62 mg of the title compound 29' as a colorless oil (yield 64%).

Workup

  1. additionThen, the reaction mixture was treated

Sources & evidence

ORD record
ord-f1f0ad4c526845b6aeefa4855d18b0b7
Source dataset
uspto-grants-1997_02
Patent number
US05599837

Reaction notes

Loading…