Hydrochloric Acid → HCID 131719819, compound

HRID 1449659Notes

Reaction equation

HRID 1449659 reaction equation
[CH2:1]([S:5]([C:8]1[CH:9]=[CH:10][C:11]2[C:15]([C:16]([C:18]3[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][N:27]4[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]4)=[CH:20][CH:19]=3)=[O:17])=[C:14]([C:33]3[CH:38]=[CH:37][C:36]([S:39]([CH2:42][CH2:43][CH2:44][CH3:45])(=[O:41])=[O:40])=[CH:35][CH:34]=3)[S:13][C:12]=2[CH:46]=1)(=O)=O)[CH2:2][CH2:3][CH3:4].CCOCC.[ClH:52]>C(OCC)(=O)C>[ClH:52].[CH2:1]([S:5][C:8]1[CH:9]=[CH:10][C:11]2[C:15]([C:16]([C:18]3[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][N:27]4[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]4)=[CH:20][CH:19]=3)=[O:17])=[C:14]([C:33]3[CH:34]=[CH:35][C:36]([S:39]([CH2:42][CH2:43][CH2:44][CH3:45])(=[O:41])=[O:40])=[CH:37][CH:38]=3)[S:13][C:12]=2[CH:46]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 23296300HCID 23296300, compound

Product 1

HCID 131719819HCID 131719819, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5.4g of [6-(n-Butylsulfonoyl)-2-[4-(n-butylsulfonoyl)phenyl]benzo[b]thien-3-yl][4-[2-(1piperidinyl)ethoxy]-phenyl]methanone was dissolved in ethyl acetate (EtOAc) and a solution of ether, saturated with HCl, was added until no more precipitate was formed. The liquid was decanted off and the solid was triturated with ether. The title compound was crystallized from hot EtOAc to afford 3.74 g, as a white powder.

Workup

  1. customwas formed
  2. customThe liquid was decanted off
  3. customthe solid was triturated with ether
  4. customThe title compound was crystallized from hot EtOAc
  5. customto afford 3.74 g

Sources & evidence

ORD record
ord-ff9414e53c7d4df1afa26b0286f6723e
Source dataset
uspto-grants-1997_02
Patent number
US05599833

Reaction notes

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