Dimethylformamide → 7-Methoxyheptanoic Acid

HRID 1449761Notes

Reaction equation

HRID 1449761 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9].CN(C)[CH:13]=[O:14]>CO>[CH3:13][O:14][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9]

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 1217237-Bromoheptanoic acid

Product 1

HCID 154095287-Methoxyheptanoic Acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared by the method of Example 1 using 7-bromoheptanoic acid (50 g, 239 mmol) instead of 12-bromoundecanoic acid and dimethylformamide (300 mL) instead or methanol as the solvent. Concentration afforded the title compound (30 g) as a pale yellow liquid and the structure verified by NMR.

Workup

  1. concentrationConcentration

Sources & evidence

ORD record
ord-a6e95cd702574fdb823077e48a9b60e0
Source dataset
uspto-grants-1997_02
Patent number
US05599947

Reaction notes

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